Title:
((2,3,9,9A-TETRAHYDRO-3-OXO-9A-SUBSTITUTED-1H-FLUORENE-7-YL)OXY)ETHANEIMIDOAMIDES, ((2,3,9,9A-TETRAHYDRO-3-OXO-9A- SUBSTITUTED-1H-FLUORENE-7-YL)OXY)ETHANEIMIDE ACID HYDRAZIDESDERIVATIVES AND SALTS
Document Type and Number:
Japanese Patent JPS6284052
Kind Code:
A
Abstract:
The invention relates to novel compounds of the formula:wherein:R is, e.g., alkyl containing from I to 5 carbon atoms;R' is NH,, NHR' or NR3R4;R2 is NH or NR3;R', R4 are,e.g., alkyl containing from I to 5 carbon atoms, or amino, provided that R3 and R4 are not both amino;wherein R' and R2 may be joined together via R3 to form a heterocyclic ring of 5 or 6 atoms containing 2 nitrogen atoms and 3 or 4 carbon atoms; or wherein R3 and R4 may be joined together to form a 5-or 6-membered ring containing one nitrogen atom, and 4 or 5 carbon atoms; andX and Y are halo or lower alkyl, such as methyl; or the pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and prevention of injury to the brain and of edema.
Inventors:
EDOWAADO JIEE KURAGOO JIYUNIYA
OTSUTOO DABURIYU UORUTAASUDORU
OTSUTOO DABURIYU UORUTAASUDORU
Application Number:
JP22632686A
Publication Date:
April 17, 1987
Filing Date:
September 26, 1986
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/16; A61K31/415; A61K31/505; A61P25/28; C07C67/00; C07C239/00; A61K31/155; C07C257/14; C07C257/22; C07D233/22; C07D233/64; C07D239/06; (IPC1-7): A61K31/155; A61K31/415; A61K31/505; C07C123/00; C07D233/64; C07D239/06
Attorney, Agent or Firm:
Masao Okabe