Title:
2,4-ジオキソ-3-キナゾリニルアリールスルホニル尿素
Document Type and Number:
Japanese Patent JP2007507551
Kind Code:
A
Abstract:
2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C1-6 alkyl; R1 is a member selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C3-5 cycloalkyl and C3-5 cycloalkyl-alkyl; R2 is a member selected from the group consisting of H, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, cyano and -C(O)R2a, wherein R2a is a member selected from the group consisting of C1-6 alkoxy and (C1-6 alkyl)0-2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of -CH2-, -CH(CH3)-, -CH2CH2-, -CH2CH(CH3)- and -CH2CH2CH2-; L1 is a linking group selected from the group consisting of a bond and -CH2-; L2 is a linking group selected from the group consisting of a bond, -NH- and -CH2-; and Ar1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine; are provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
Inventors:
Scarborough, Robert M.
Fan, woolin
Pandy, Anjali
Bower, Shawn M.
Tsang, Xiao Ming
Zia, Zao Tson Jay.
Fan, woolin
Pandy, Anjali
Bower, Shawn M.
Tsang, Xiao Ming
Zia, Zao Tson Jay.
Application Number:
JP2006534290A
Publication Date:
March 29, 2007
Filing Date:
September 29, 2004
Export Citation:
Assignee:
Portra Pharmaceuticals, Inc.
International Classes:
C07D409/12; A61K31/517; A61K45/00; A61P7/02; A61P9/10; A61P9/14; A61P41/00; A61P43/00; C07D409/14; C07D417/14; A61K
Domestic Patent References:
| JP2003522177A | 2003-07-22 |
Foreign References:
| WO2003011872A1 | 2003-02-13 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita