Title:
２，４−二置換１，３−オキサチオランヌクレオシドの鏡像異性体分割
Document Type and Number:
Japanese Patent JP5690731
Kind Code:
B2
Abstract:
Single enantionmers of compounds of formula (B), in either the cis or trans configuration, wherein R1 and R2 are as defined herein, can be separated from enantiomeric mixtures thereof by reacting the compound with an acid to produce a conglomerate salt that has the following characteristics: the IR spectrum of the salt of the racemic compound, a 1:1 mixture of (−) and (+) crystals, is identical to that of the each of the single enantiomer, and the salt of the racemic compound has a melting point lower that that of either single enantiomer. The conglomerate salt is then separated by preferential crystallization.
Inventors:
ダン・サイモン
ドラゴス・ヴィジティウ
ジャン−エリック・ラコステ
ドラゴス・ヴィジティウ
ジャン−エリック・ラコステ
Application Number:
JP2011525634A
Publication Date:
March 25, 2015
Filing Date:
September 05, 2008
Export Citation:
Assignee:
シャイアー カナダ インコーポレイテッドＳｈｉｒｅ Ｃａｎａｄａ Ｉｎｃｏｒｐｏｒａｔｅｄ
International Classes:
C07D411/04; A61K31/513
Attorney, Agent or Firm:
Aoyama 葆
Yamada Takuji
Michiko Matsutani
Ochiai 康
Yamada Takuji
Michiko Matsutani
Ochiai 康