【発明の名称】1α-ヒドロキシ-24-オキソ-ビタミンD↓3およびその製造法

Title:

【発明の名称】1α-ヒドロキシ-24-オキソ-ビタミンD↓3およびその製造法

Document Type and Number:

Japanese Patent JPS5822479

Kind Code:

B2

Abstract:

Novel 1 alpha ,3 beta -dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof. Said novel 1 alpha -hydroxy-24-oxovitamin D3 and said novel intermediates are also useful as the intermediates of 1 alpha ,24-dihydroxyvitamin D3. 1 alpha ,3 beta -Dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof are prepared from fucosterol via 1 alpha ,3 beta -diprotected hydroxy-24(24)-ethylenedioxycholest-5-ene. 1 alpha -hydroxy-24-oxovitamin D3 is prepared by irradiation with ultraviolet rays to 1 alpha ,3 beta -dihydroxy-24-oxocholesta-5,7-diene or a hydroxyl group-protected derivatives thereof, isomerization using heat energy, and, when necessary, elimination of the protecting groups.

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Inventors:

TAKESHITA TOORU
FUTAKI TAKAO
KAWASHIMA HIROYUKI
SAKAUCHI KYOSHI

Application Number:

JP10667777A

Publication Date:

May 09, 1983

Filing Date:

September 07, 1977

Export Citation:

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Assignee:

TEIJIN LTD

International Classes:

A61K31/59; A61P3/02; C07C67/00; C07C401/00; C07J9/00; C07J17/00; C07J51/00; (IPC1-7): C07C172/00

Attorney, Agent or Firm:

Maeda Junhiro

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