Title:
２５－ヒドロキシコレカルシフェロール一水和物結晶、その製造方法及びそれを用いたマイクロエマルション
Document Type and Number:
Japanese Patent JP7072676
Kind Code:
B2
Abstract:
The present invention provides a 25-hydroxycholecalciferol monohydrate crystal, a preparation method thereof, and a microemulsion using the 25-hydroxycholecalciferol monohydrate crystal. The X-ray powder diffraction spectrum of the 25-hydroxycholecalciferol monohydrate crystal of the present invention shows characteristic peaks at 2θ of 10.035°, 11.623°, 14.631°, 15.054°, 15.551°, 16.471°, 17.198°, 19.002°, 19.628°, 20.109°, 21.886°, 23.113°, 23.661°, 24.701°, 25.220°, 25.440°, and 28.527°. The 25-hydroxycholecalciferol monohydrate crystal of the present invention can effectively enhance the stability of 25-hydroxycholecalciferol, and is more beneficial to the production and storage of related preparations, and thus biological characteristics of 25-hydroxycholecalciferol can be effectively utilized.
Inventors:
Tan Fay
Khao Jin Dan
Rishin
Jan Chao
Luo Hao
Li Chan Chan
Kaoshi
Shu Liang
Khao Jin Dan
Rishin
Jan Chao
Luo Hao
Li Chan Chan
Kaoshi
Shu Liang
Application Number:
JP2020564987A
Publication Date:
May 20, 2022
Filing Date:
August 07, 2018
Export Citation:
Assignee:
SHANDONG HAINENG BIOENGINEERING CO., LTD.
SHANDONG HAINENG PHARMACEUTICAL CO., LTD.
SHANDONG HAINENG PHARMACEUTICAL CO., LTD.
International Classes:
C07C401/00; A23K20/174
Domestic Patent References:
| JP2008504369A | ||||
| JP2005519894A | ||||
| JP2011529081A |
Foreign References:
| CN107296152A |
Other References:
Trinh-Toan et al.,Journal of The Chemical Society,1977年,No.4,p.393-401
Attorney, Agent or Firm:
Washeda International Patent Office