Title:
（２Ｒ，６Ｒ）−ヒドロキシノルケタミンの合成および精製のためのプロセス
Document Type and Number:
Japanese Patent JP2021527038
Kind Code:
A
Abstract:
（２Ｒ，６Ｒ）−ヒドロキシノルケタミンの調製のためのプロセスが提供される。プロセスはクロマトグラフィー精製を必要とせず、８工程で、２６％の全収率および９７％超の純度で、（２Ｒ，６Ｒ）−ヒドロキシノルケタミンを与える。
Inventors:
Thomas Craig Jay
Morris Patrick Joseph
Castrudin Richard Andrew
Bourne Samuel Lawrence
Morris Patrick Joseph
Castrudin Richard Andrew
Bourne Samuel Lawrence
Application Number:
JP2020567577A
Publication Date:
October 11, 2021
Filing Date:
June 04, 2019
Export Citation:
Assignee:
The United States of America, As Represented by The Secretary, Department of Health and Human Services
International Classes:
C07C221/00; C07C45/63; C07C49/813; C07C225/20; C07C249/02; C07C251/24
Foreign References:
| WO2017165878A1 | 2017-09-28 | |||
| US20030224447A1 | 2003-12-04 |
Other References:
PATRICK J. MORRIS ET AL.: "Synthesis and N-methyl-D-aspartate (NMDA)eceptor Activity of Ketamine Metabolites", ORGANIC LETTERS, vol. volume 19, issue 17, JPN6023022773, 22 August 2017 (2017-08-22), pages 4572 - 4575, ISSN: 0005210929
YIBAI LI ET AL.: "The CYP2B6*6 Allele Significantly Alters the N-Demethylation of Ketamine Enantiomers In Vitro", DRUG METABOLISM & DISPOSITION, vol. Volume 41, Issue 6, JPN6023022772, 1 June 2013 (2013-06-01), pages 1264 - 1272, ISSN: 0005210930
YIBAI LI ET AL.: "The CYP2B6*6 Allele Significantly Alters the N-Demethylation of Ketamine Enantiomers In Vitro", DRUG METABOLISM & DISPOSITION, vol. Volume 41, Issue 6, JPN6023022772, 1 June 2013 (2013-06-01), pages 1264 - 1272, ISSN: 0005210930
Attorney, Agent or Firm:
Patent Corporation yki International Patent Office