Title:
プロコラ-ゲンC-プロテイナ-ゼ阻害剤として有用な3-オキサ(ジア)ゾリルプロパノヒドロキサム酸
Document Type and Number:
Japanese Patent JP4055993
Kind Code:
B2
Abstract:
Compound of formula (I), wherein X is C1-6 alkylene or C2-6 alkenylene, each of which is optionally substituted by one or more flluorine atoms; R is aryl or C3-8 cycloalkyl optionally substituted by one or more fluorine atoms; W is N or CZ; are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP.
Inventors:
Woo Datta
Paul Vincent Fish
Kim james
Gavin Alistair Whitlock
Paul Vincent Fish
Kim james
Gavin Alistair Whitlock
Application Number:
JP2002551543A
Publication Date:
March 05, 2008
Filing Date:
December 07, 2001
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07D263/34; A61K31/421; A61K31/422; A61K31/4245; A61K31/4439; A61K31/496; A61K31/5377; A61P17/00; A61P17/02; A61P43/00; C07B61/00; C07C235/74; C07C259/14; C07C311/06; C07D205/04; C07D211/60; C07D211/96; C07D263/16; C07D263/32; C07D271/06; C07D271/07; C07D413/04; C07D413/06; C07D413/12; C07D417/06; C07D521/00
Domestic Patent References:
| JP2003519133A | ||||
| JP10500965A | ||||
| JP9503492A | ||||
| JP9509940A | ||||
| JP11504015A |
Other References:
Journal of Medicinal Chemistry,1998年,Vol.41/No.8,p.1209-1217
Tetrahedron,1998年,Vol.54/No.45,p.13825-13832
Synlett,1998年,No.6,p.637-639
Bioorganic & Medicinal Chemistry Letters,2000年11月20日,Vol.10/No.22,p.2513-2516
Tetrahedron,1998年,Vol.54/No.45,p.13825-13832
Synlett,1998年,No.6,p.637-639
Bioorganic & Medicinal Chemistry Letters,2000年11月20日,Vol.10/No.22,p.2513-2516
Attorney, Agent or Firm:
Yoshinobu Murofushi