Title:
3-置換-2(アリールアルキル)-1-アザビシクロアルカンおよびこれらの使用方法
Document Type and Number:
Japanese Patent JP5211183
Kind Code:
B2
Abstract:
The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
Inventors:
Anatoly A Maslov
Josef Kurtsk
Lan Maio
Angiela es seamans
Teresa Young Peter Phillips
Jeffrey Daniel Schmidt
Craig Harrison Miller
Josef Kurtsk
Lan Maio
Angiela es seamans
Teresa Young Peter Phillips
Jeffrey Daniel Schmidt
Craig Harrison Miller
Application Number:
JP2011021779A
Publication Date:
June 12, 2013
Filing Date:
February 03, 2011
Export Citation:
Assignee:
Targacept, Incorporated
International Classes:
C07D453/02; A61K31/444; A61K51/00; A61P43/00; C07D453/04; C07D471/08; C07D487/08
Domestic Patent References:
| JP2002531564A | ||||
| JP10087661A |
Foreign References:
| WO2002016358A1 |
Other References:
HEESCHEN, C. et al.,J. Clin. Invest.,2002年,Vol.110, No.4,p.527-36
Attorney, Agent or Firm:
Yoshio Kawaguchi
Katsuma Osaki
Katsuma Osaki