Title:
メタロ−β−ラクタマーゼ阻害剤としての３−テトラゾリル−ベンゼン−１，２−ジスルホンアミド誘導体
Document Type and Number:
Japanese Patent JP6409141
Kind Code:
B2
Abstract:
and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
Inventors:
Bennett, Frank
Jean, Jinron
Pastel Nark, Alexandre
Don, Shuzy
Goo, Shin
Scott, Jack Dee
Tan, High Chew
Jiao, Chee Chan
Howan, Yui Hoa
Yang, Dixie
Young, Catherine
Xiao, Lee
Jane, Jibo
Fu Jiang Min
Jean, Jinron
Pastel Nark, Alexandre
Don, Shuzy
Goo, Shin
Scott, Jack Dee
Tan, High Chew
Jiao, Chee Chan
Howan, Yui Hoa
Yang, Dixie
Young, Catherine
Xiao, Lee
Jane, Jibo
Fu Jiang Min
Application Number:
JP2017566836A
Publication Date:
October 17, 2018
Filing Date:
June 24, 2016
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D403/14; A61K31/198; A61K31/407; A61K31/41; A61K31/4184; A61K31/424; A61K31/428; A61K31/43; A61K31/431; A61K31/4439; A61K31/529; A61K31/546; A61K31/551; A61K33/22; A61K45/00; A61P31/04; C07D257/04; C07D401/10; C07D403/10; C07D417/10; C07D417/14
Domestic Patent References:
| JP2015506360A |
Other References:
FAST, W. et al.,Metallo-β-lactamase: Inhibitors and reporter substrates,Biochimica et Biophysica Acta,2013年,1834(8),pp. 1648-1659
BUYNAK, J. D.,β-Lactamase inhibitors: a review of the patent literature (2010 - 2013),Expert Opinion on Therapeutic Patents,2013年,23(11),pp. 1469-1481
TONEY, J. H. et al.,Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors,Bioorganic & Medicinal Chemistry Letters,1999年,9(18),pp. 2741-2746
BUYNAK, J. D.,β-Lactamase inhibitors: a review of the patent literature (2010 - 2013),Expert Opinion on Therapeutic Patents,2013年,23(11),pp. 1469-1481
TONEY, J. H. et al.,Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors,Bioorganic & Medicinal Chemistry Letters,1999年,9(18),pp. 2741-2746
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama