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Title:
3-HYDROXYALKANOIC ACID DERIVATIVE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPS63233950
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by formula I [R1 is hydroxyalkyl which may be protected; R2 is alkyl; R3 is R1, H or alkyltrisubstituted silyl; R4 is (substituted)OH or (substituted)amino or a salt thereof.

EXAMPLE: 5-Benzyloxy-2-[1-tertiary butyldimethylsilyloxyethyl)-3-hydroxy-N-me thoxy-4-methylpentanamide.

USE: An intermediate for producing an 1-alkylcarbapenem compound having strong antibacterial action on many pathogenic bacteria.

PREPARATION: For example, a compound shown by formula II is reacted with a compound shown by formula III (R4 is substituted OH; R5 is OH-protecting group) to give a corresponding compound shown by formula I.


Inventors:
NAKAI TAKESHI
SHIRAI FUMIYUKI
Application Number:
JP3233788A
Publication Date:
September 29, 1988
Filing Date:
February 15, 1988
Export Citation:
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Assignee:
FUJISAWA PHARMACEUTICAL CO
International Classes:
C07D205/08; C07C51/00; C07C59/01; C07C59/10; C07C67/00; C07C69/675; C07C231/00; C07C231/02; C07C235/06; C07C239/00; C07C239/20; C07C259/06; C07D205/085; C07F7/18; (IPC1-7): C07C59/01; C07C59/10; C07C69/675; C07C83/04; C07C103/167; C07C103/175; C07D205/08; C07F7/18