Title:
3-KETO HMG-COA REDUCTASE INHIBITOR
Document Type and Number:
Japanese Patent JPH0324033
Kind Code:
A
Abstract:
NEW MATERIAL: A compd. represented by formula I or II [R1 is (substd.) alkyl, alkoxy, alkenyl, (substd.) cycloalkyl, (substd.) phenyl, amino, mono-or dialkylamino, piperdinyl, pyrrolidinyl or R3S (R3 is alkyl or substitutable phenyl); and R2 is H, CH3 or CH2OH and Z is H].
EXAMPLE: 6(R)-[2-[8(S)-2-methylbutylyloxy)-2(S)-methyl-3-oxo-1,2,3,7,8,8a (R)- hexahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one.
USE: A remedy of hypercholesterolemia and hyperlipemia.
PROCESS: A compd. wherein R2 is CH3 is obtained by biological conversion of lovastatin or symbastatin having a 6-methyl group by bacteria belonging to the genus Nocardia.
Inventors:
HENRII JIYOSHIYUA
KENESU II UIRUSON
MAIKERU ESU SHIYUWARUTSU
TA JIII RII
JIERARUDO II SUTOTSUKAA
KENESU II UIRUSON
MAIKERU ESU SHIYUWARUTSU
TA JIII RII
JIERARUDO II SUTOTSUKAA
Application Number:
JP17820489A
Publication Date:
February 01, 1991
Filing Date:
July 12, 1989
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C12P7/42; A61K31/19; A61K31/215; A61K31/22; A61K31/235; A61K31/35; A61K31/365; A61P3/06; A61P9/10; A61P43/00; C07C13/38; C07C53/136; C07C69/013; C07C69/02; C07C69/30; C07C69/738; C07C69/757; C07C271/34; C07C317/44; C07C323/52; C07C323/61; C07C323/62; C07D309/00; C07D309/30; C07D309/38; C07D405/00; C12N9/02; C12N9/99; C12P7/62; C12P11/00; C12P17/06; C12R1/365; A61K; C07D; (IPC1-7): A61K31/215; A61K31/365; C07C69/013; C07C271/34; C07C317/44; C07C323/52; C07C323/61; C07C323/62; C07D309/30; C12N9/99; C12P7/42; C12P7/62; C12P11/00; C12P17/06
Attorney, Agent or Firm:
Masao Okabe (3 others)
Next Patent: JPH0324034