Title:
3-(UREIDOCYCLOHEXYLAMINO)-PROPAN-1,2-DIOL DERIVATIVE, MANUFACTURE AND MEDICINE
Document Type and Number:
Japanese Patent JPS5931753
Kind Code:
A
Abstract:
Compounds with cardiovascular action of the formula I in which Ar denotes a (monocyclic or, if desired, partially hydrogenated bicyclic) carbocyclic or heterocyclic, substituted or unsubstituted aromatic radical, R represents hydrogen, alkanoyl or aroyl, R1 and R2, independently of one another, denote hydrogen or lower alkyl or R1 and R2 together denote alkylene having 2 to 7 carbon atoms which separate the two nitrogen atoms by 2 to 4 carbon atoms, R3 and R4, independently of one another, represent hydrogen or lower alkyl, and X denotes oxo (O) or thio (S), their salts, in particular therapeutically useful salts, and processes for their preparation, pharmaceutical preparations containing these compounds and their therapeutic use. They can be prepared, for example, by reduction of a compound corresponding to the formula I, in which instead of the 1,4-cyclohexylene radical a 1,4-phenylene radical is present.
Inventors:
RINKAAN HAABEI WAANAA
NEBIRU FUOODO
NEBIRU FUOODO
Application Number:
JP9257683A
Publication Date:
February 20, 1984
Filing Date:
May 27, 1983
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
A61K31/415; A61P9/12; C07C43/23; C07C67/00; C07C239/00; C07C275/26; C07C275/40; C07C301/00; C07C303/38; C07C303/40; C07C311/08; C07C313/00; C07C315/04; C07C317/22; C07C319/20; C07C323/20; C07C325/00; C07C335/14; C07D233/32; C07D233/36; C07D233/42; C07D303/24; C07D401/12; C07D403/12; C07D417/12; (IPC1-7): A61K31/415; C07C127/15; C07C143/74; C07C147/00; C07C149/36; C07C157/05
Attorney, Agent or Firm:
Aoki Akira