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Title:
3BATA,17BETA-HYDROXY-SUBSTITUTED STEROID AND RELATED STEROID COMPOUNDS
Document Type and Number:
Japanese Patent JPH02174793
Kind Code:
A
Abstract:

NEW MATERIAL: A compd. represented by formula I [wherein R1 is OH or a group represented by formula II (R5 is a 1-10C alkyl); R2 is OH, = O or a group represented by formula II; and R3 is CH3 or a 1-4C alkyl].

EXAMPLE: 10-(2-Pulpinyl)-19-norandrost-5-ene-3β,17β-diol.

USE: This new material is used as an aromatase inhibitor and useful as a therepeutic agent for estrogen dependence.

PROCESS: A compd. represented by formula III is reacted with sodium boron hydride to obtain the compd. represented by formula I (wherein R1 and R2 are OH).


Inventors:
JIYON ONIIRU JIYONSUTON
JIIN WAAUITSUKU HORUBAATO
Application Number:
JP1989000278752
Publication Date:
July 06, 1990
Filing Date:
October 27, 1989
Export Citation:
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Assignee:
MERRELL DOW PHARMA
International Classes:
A61K31/565; A61P43/00; C07J1/00; (IPC1-7): A61K31/565; C07J1/00