4-Amino-6-Phenyl-5,6-dihydroimidazole [1,5-A] pyrazine derivative as an inhibitor of β-secretase (BACE)

Japanese Patent JP6325092

B2

The present invention relates to novel 5,6-dihydroimidazo[1,5-a]pyrazinyl derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, in particular BACE1 and/or BACE2 (wherein BACE1, is also known as Asp2, or memapsin2 and BACE2 is also known as Asp1, Memapsin 1 or DRAP). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia of the Alzheimer's type, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.

Ulrich, Daniel
Dyssen, Henricus, Jecobus, Maria
Sulkin, michael

JP2016518499A

May 16, 2018

June 12, 2014

Click for automatic bibliography generation  

Janssen Pharmaceuticals N.B.

C07D487/04; A61K31/4985; A61K31/506; A61P1/00; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P17/00; A61P19/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00

JP2012512831A

WO2012120023A1
WO2012085038A1
WO2012057247A1

Hiroshi Kobayashi
Norio Omori
Junko Kobayashi
Ryo Hoshikawa
Yasuhito Suzuki

Previous Patent: A stole departure method and a stole start device for a parallel hybrid vehicle

Next Patent: JPS6325093