Title:
4-アミノメチルベンズアミジン誘導体及び第VIIa因子阻害剤としてのその使用
Document Type and Number:
Japanese Patent JP2008512364
Kind Code:
A
Abstract:
The invention is concerned with novel 4-aminomethyl benzamidine derivatives of formula (I) wherein Ar and X are as defined in the description and in the claims, as well as prodrugs and pharmaceutically acceptable salts thereof These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
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Inventors:
Banner, david william
Mall, peter
Obst, Ulrike
Christoph Martin, Stahl
Mall, peter
Obst, Ulrike
Christoph Martin, Stahl
Application Number:
JP2007529330A
Publication Date:
April 24, 2008
Filing Date:
August 29, 2005
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C257/18; A61K31/18; A61K31/192; A61K31/198; A61K31/4015; A61K31/4035; A61K31/415; A61K31/4164; A61K31/4184; A61K31/42; A61K31/425; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4465; A61K31/5375; A61K31/66; A61P7/02; A61P9/10; A61P35/00; C07C255/54; C07C255/58; C07C259/18; C07C303/40; C07C311/04; C07C311/08; C07C311/13; C07C311/21; C07D207/27; C07D209/48; C07D211/58; C07D213/18; C07D213/30; C07D213/53; C07D213/75; C07D231/14; C07D233/64; C07D235/04; C07D261/14; C07D261/18; C07D275/02; C07D295/10; C07D295/12
Domestic Patent References:
| JP2004529905A | 2004-09-30 | |||
| JP2002507968A | 2002-03-12 | |||
| JP2004522759A | 2004-07-29 |
Foreign References:
| WO2002072558A1 | 2002-09-19 | |||
| WO1999029670A2 | 1999-06-17 | |||
| WO1999028297A1 | 1999-06-10 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito