Title:
ＣＣＲ２の４−アゼチジニル−１−ヘテロ原子結合シクロヘキサンアンタゴニスト
Document Type and Number:
Japanese Patent JP5685581
Kind Code:
B2
Abstract:
The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
Inventors:
ツアン，スーチン
ハフナゲル，ヘザー・ラエ
スイ，ツイーフア
ハフナゲル，ヘザー・ラエ
スイ，ツイーフア
Application Number:
JP2012506227A
Publication Date:
March 18, 2015
Filing Date:
April 15, 2010
Export Citation:
Assignee:
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪＡＮＳＳＥＮ ＰＨＡＲＭＡＣＥＵＴＩＣＡ ＮＡＡＭＬＯＺＥ ＶＥＮＮＯＯＴＳＣＨＡＰ
International Classes:
C07D401/08; A61K31/397; A61K31/4025; A61K31/4035; A61K31/4155; A61K31/416; A61K31/4178; A61K31/42; A61K31/428; A61K31/4427; A61K31/501; A61K31/506; A61K31/536; A61P1/02; A61P1/04; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/06; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D403/04; C07D403/08; C07D403/12; C07D405/04; C07D405/12; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Patent business corporation Odajima patent firm