Title:
4-ジメチルアミノ酪酸誘導体
Document Type and Number:
Japanese Patent JP5474047
Kind Code:
B2
Abstract:
This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.
Inventors:
Angel Covich, Myllana
Ceccarelli, Simona Em
Chaumienne, Odile
Kaplan, Gerald Lewis
Matthew, Patrizio
Tilly, Jefferson Wright
Ceccarelli, Simona Em
Chaumienne, Odile
Kaplan, Gerald Lewis
Matthew, Patrizio
Tilly, Jefferson Wright
Application Number:
JP2011505469A
Publication Date:
April 16, 2014
Filing Date:
April 20, 2009
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C235/12; A61K31/197; A61K31/381; A61K31/426; A61K31/4406; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P43/00; C07C231/02; C07C233/51; C07C235/34; C07C237/12; C07C273/18; C07C275/16; C07C315/04; C07C317/44; C07D213/56; C07D277/20; C07D277/30; C07D333/24
Domestic Patent References:
| JP2003513002A | ||||
| JP2007522165A |
Foreign References:
| WO2006092204A1 | ||||
| WO2008015081A1 | ||||
| WO2008109991A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito