Title:
4-HETEROCYCLIC FUSED-RING ARYLPIPERIDINE DERIVATIVES
Document Type and Number:
Japanese Patent JP2003034689
Kind Code:
A
Abstract:
To provide a production method for compounds that are useful for the prevention and treatment of diseases such as pruritis which are mediated by an opium receptor.
The production method for the compounds represented by general formula I (wherein, Het1 is a 5-, 6- or 7-membered heterocyclic ring which contains at least one nitrogen atom and optionally one or more hetero atoms selected from oxygen and sulfur, and T, X, R1, R2 and R3 are each a substituent) and an intermediate for synthesis used in the production method are provided. The compounds presented by general formula I have a Ki value of 4000 nM or less to the μ-receptor and affinity with the δ- and γ-opioides.
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Inventors:
RICHARD EDWARD ARMOUR
BRONK BRIAN SCOTT
STEPHEN PAUL GIBSON
ROBERTS LEE RICHARD
IVAN TOMASINI
KIMBERLY BERIEE
BRONK BRIAN SCOTT
STEPHEN PAUL GIBSON
ROBERTS LEE RICHARD
IVAN TOMASINI
KIMBERLY BERIEE
Application Number:
JP2002142681A
Publication Date:
February 07, 2003
Filing Date:
May 25, 2000
Export Citation:
Assignee:
PFIZER
International Classes:
C07D211/28; A61K31/4427; A61K31/4468; A61K31/451; A61K31/454; A61P1/00; A61P1/08; A61P1/10; A61P1/14; A61P3/04; A61P9/00; A61P15/10; A61P17/00; A61P17/02; A61P17/04; A61P25/00; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; A61P37/08; A61P43/00; C07B61/00; C07D211/26; C07D401/04; C07D413/04; (IPC1-7): C07D401/04; C07D211/26; C07D413/04
Attorney, Agent or Firm:
Murobushi Yoshinobu