Title:
5-置換2-アリール-4-ピリミジノン
Document Type and Number:
Japanese Patent JP2004504302
Kind Code:
A
Abstract:
Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
Inventors:
Kevin Jay Hodgets
Dario drell
Dario drell
Application Number:
JP2002512146A
Publication Date:
February 12, 2004
Filing Date:
July 18, 2001
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
G01N33/50; A61J1/14; A61K31/513; A61K31/5377; A61K31/541; A61K31/55; A61P1/04; A61P1/12; A61P1/14; A61P3/04; A61P5/14; A61P9/04; A61P9/12; A61P15/08; A61P17/06; A61P19/02; A61P25/18; A61P25/22; A61P25/24; A61P29/00; A61P37/08; A61P43/00; C07D239/34; C07D239/36; C07D239/46; C07D239/47; C07D239/52; C12Q1/02; G01N33/15; G01N33/58; (IPC1-7): C07D239/34; A61J1/14; A61K31/513; A61K31/5377; A61K31/541; A61K31/55; A61P1/04; A61P1/12; A61P1/14; A61P3/04; A61P5/14; A61P9/04; A61P9/12; A61P15/08; A61P17/06; A61P19/02; A61P25/18; A61P25/22; A61P25/24; A61P29/00; A61P37/08; A61P43/00; C07D239/47; C12Q1/02; G01N33/15; G01N33/50; G01N33/58
Attorney, Agent or Firm:
Norio Saeki
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