抗ウイルス薬としての5-置換1-フェニル-1,5-ジヒドロ-ピリド’3,2B!インドール-2-オンおよび類似物

Title:

抗ウイルス薬としての5-置換1-フェニル-1,5-ジヒドロ-ピリド’3,2B!インドール-2-オンおよび類似物

Document Type and Number:

Japanese Patent JP2007538049

Kind Code:

A

Abstract:

Compounds of formula (I) the N-oxides, salts, stereoisomeric forms, prodrugs, esters and metabolites thereof, wherein X is NR², O, S, SO, SO₂; R¹is hydrogen, cyano, halo, a carbonyl derivative, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C_1-4alkyl)-methanimidamidyl, Het₁or Het₂; n is 1, 2 or 3; R²is (i) aryl substituted with a radical -COOR⁴; (ii) C_1-10alkyl, C_2-10alkenyl, C_3-7cycloalkyl, substituted with aryl which is substituted with a radical -COOR⁴; (iii) C_1-10alkyl, C_2-10alkenyl, C_3-7cycloalkyl, substituted with -NR^5a-C(-NR^5b)-NR^5cR^5d, -O-NR^5a-C(-NR^5b)-NR^5cR^5d, -sulfonyl-R⁶, -NR⁷R⁸, -NR⁹R¹⁰, a radical (a-1), (a-2), (a-3), (a-4), (a-5); or (iv) a radical of formula: (a-6), (b-2), -C_pH_2p-CH(OR¹⁴)-C_qH_2q-R¹⁵; -CH₂-CH₂-(O-CH₂-CH₂)_m-OR¹⁴; -CH₂-CH₂-(O-CH₂-CH2)_m-NR^17aR^17b; R³is nitro, cyano, amino, halo, hydroxy, C_1-4alkyloxy, a carbonyl derivative, methanimidamidyl, mono- or di(C_1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het₁.

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Inventors:

Kestrein, Bald Rudolph Romani
Canal, Maxim Francis Jiyan-Marie Guislan
Van de Breken, Wim
La Boisson, Pierre Jean-Marie Bernardo
Chururu, Dominique Louis Nestor Guislan
Wiegerink, Piet Tom Belt Paul

Application Number:

JP2007517252A

Publication Date:

December 27, 2007

Filing Date:

May 17, 2005

Export Citation:

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Assignee:

Tabebotech Pharmaceuticals Limited

International Classes:

C07D471/04; A61K31/4355; A61K31/437; A61K31/4545; A61K31/496; A61K31/5377; A61K31/541; A61P31/18; A61P43/00; C07D491/048

Domestic Patent References:

JP2006508145A

2006-03-09

Foreign References:

WO2004046143A1

2004-06-03

Attorney, Agent or Firm:

Heikichi Odashima

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