Title:
5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS
Document Type and Number:
Japanese Patent JP2018199709
Kind Code:
A
Abstract:
To provide novel compounds having a neprilysin inhibition activity.SOLUTION: In one aspect, the invention relates to compounds having the formula (I): where R, R, R, and R-Rare as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds. The compounds of the invention are expected to be useful and advantageous as therapeutic agents for treating conditions such as hypertension and heart failure.SELECTED DRAWING: None
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Inventors:
MELISSA FLEURY
ANNE-MARIE BEAUSOLEIL
ADAM D HUGHES
LONG DANIEL D
DONNA A A WILTON
ANNE-MARIE BEAUSOLEIL
ADAM D HUGHES
LONG DANIEL D
DONNA A A WILTON
Application Number:
JP2018162694A
Publication Date:
December 20, 2018
Filing Date:
August 31, 2018
Export Citation:
Assignee:
THERAVANCE BIOPHARMA R&D IP LLC
International Classes:
C07D213/81; A61K31/415; A61K31/4164; A61K31/4192; A61K31/4196; A61K31/421; A61K31/4245; A61K31/44; A61K31/505; A61K45/00; A61P9/00; A61P9/12; A61P13/12; C07D231/14; C07D249/04; C07D263/34; C07D271/07; C07D407/12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto