Title:
5員環へテロ環誘導体及びその医薬用途
Document Type and Number:
Japanese Patent JP5378988
Kind Code:
B2
Abstract:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to 5-membered heterocyclic derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH 2 , halogen, haloalkyl and the like; X 1 and X 2 independently represent CR 2 or N; R 2 represents H, alkyl and the like; R 1 represents halogen, cyano, haloalkyl, A-D-E-G-L-M, -N(-D-L-M) 2 and the like, in the formula, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SO 2 and the like.
Inventors:
Kazuo Shimizu
Yasushi Takigawa
Hideki Fujikura
Masato Iizuka
Hiratochi Masahiro
Norihiko Kikuchi
Yasushi Takigawa
Hideki Fujikura
Masato Iizuka
Hiratochi Masahiro
Norihiko Kikuchi
Application Number:
JP2009509372A
Publication Date:
December 25, 2013
Filing Date:
April 10, 2008
Export Citation:
Assignee:
Kissei Pharmaceutical Co., Ltd.
International Classes:
C07D207/34; A61K31/402; A61K31/4025; A61K31/404; A61K31/415; A61K31/4155; A61K31/427; A61K31/4439; A61K31/454; A61K31/5377; A61K45/00; A61P13/02; A61P19/06; A61P43/00; C07D231/14; C07D231/16; C07D231/20; C07D231/38; C07D231/40; C07D401/04; C07D403/04; C07D405/04; C07D405/06; C07D409/04; C07D409/12; C07D417/04
Domestic Patent References:
| JP2000001431A | 2000-01-07 | |||
| JP3220987B2 | 2001-10-22 | |||
| JPH08511243A | 1996-11-26 | |||
| JP2000001431A | 2000-01-07 | |||
| JP3220987B2 | 2001-10-22 |
Foreign References:
| WO2003042181A1 | 2003-05-22 | |||
| WO1997046530A1 | 1997-12-11 | |||
| WO2006066937A2 | 2006-06-29 | |||
| WO2003073999A2 | 2003-09-12 | |||
| US20030069242A1 | 2003-04-10 | |||
| US6511974B1 | 2003-01-28 | |||
| US5760068A | 1998-06-02 |
Other References:
JPN6013012807; Ｔｅｔｒａｈｅｄｒｏｎ ５２，１２, 1996, ４４８５-４４９４
Attorney, Agent or Firm:
Nobuko Yanagi