Title:
7α―(5―メチルアミノペンチル)―エストラトリエン、その製造方法、この7α―(5―メチルアミノペンチル)―エストラトリエンを含有する医薬製剤、並びに医薬を製造するためのその使用
Document Type and Number:
Japanese Patent JP4116080
Kind Code:
B2
Abstract:
This invention describes the new 7alpha-(5-methylaminopentyl)-estratrienes of general formula Iin whichR2 stands for a hydrogen or fluorine atom,R17 stands for a hydrogen atom, a methyl or ethinyl group,n stands for 2, 3 or 4, andx stands for 0, 1 or 2.The new compounds are strong, pure antiestrogens and can be used for the production of pharmaceutical agents for treatment of estrogen-dependent diseases, for example, breast cancer, endometrial carcinoma, prostatic hyperplasia, anovulatory infertility and melanoma.
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Inventors:
Bitterer, dieter
Ballman, Rolf
Heinrich, Nikolaus
Crawl, Yoruk
Sauer, Gerhard
Nishino Yukishige
Pershok, Kirsten
Martin, Sneijder
Egerean Tang, Crysta
Lichtner, rosemary
Ballman, Rolf
Heinrich, Nikolaus
Crawl, Yoruk
Sauer, Gerhard
Nishino Yukishige
Pershok, Kirsten
Martin, Sneijder
Egerean Tang, Crysta
Lichtner, rosemary
Application Number:
JP54159497A
Publication Date:
July 09, 2008
Filing Date:
May 26, 1997
Export Citation:
Assignee:
Schering Akchen Gezel Shaft
International Classes:
A61K31/565; A61K31/00; C07J41/00; A61P5/24; A61P35/00; C07J1/00; C07J17/00; C07J31/00; C07J51/00
Domestic Patent References:
| JP6097995A | ||||
| JP2243698A |
Attorney, Agent or Firm:
Takashi Ishida
Kazuhiro Nakamura
Toshio Toda
Masaya Nishiyama
Higuchi Souji
Kazuhiro Nakamura
Toshio Toda
Masaya Nishiyama
Higuchi Souji