Title:
免疫賦活性イノシン一リン酸の5’-ヌクレオチダーゼ抵抗性誘導体およびその使用
Document Type and Number:
Japanese Patent JP4841413
Kind Code:
B2
Abstract:
To provide a 5'-nucleotidase-resistant derivative of immunopotentiating inosine-mono-phosphoric acid that has more larger immunopotentiating activity, higher stability and resistance to 5'-nucleotidase.
This invention relates to 5'-nucleotidase-resistant inosine-5'-monophosphoric acid and a method for producing the derivative and inosine-5'-monophosphoric acid is chemically changed to a compound represented by formula (I) (wherein R is selected from the group consisting of an alkyl, an alkoxy and secondary amino compound) and the biological activity of the inosine-5'-monophosphoric acid is allowed to retain in vivo.
COPYRIGHT: (C)2007,JPO&INPIT
Inventors:
John W Hardin
Sorolla Alfredo Gener
Car Noel Masiehi
Sorolla Alfredo Gener
Car Noel Masiehi
Application Number:
JP2006330014A
Publication Date:
December 21, 2011
Filing Date:
December 06, 2006
Export Citation:
Assignee:
University of South Florida
International Classes:
C07H19/00; C07H1/00; A61K31/7076; A61P37/04; A61P43/00
Other References:
SOSA, M. et al.,International Journal of Immunopharmacology,Pergamon Press Ltd.,1992年,Vol.14/No.7,p.1259-1266
HADDEN, J.W. et al.,International Journal of Immunopharmacology,Pergamon Press Ltd.,1992年,Vol.14/No.4,p.555-563
SOSA, M. et al.,Annals of the New York Academy of Sciences,米国,1993年,Vol.685 (Immunomodulating Drugs),p.458-463
HADDEN, J.W. et al.,International Journal of Immunopharmacology,Pergamon Press plc.,1991年,Vol.13/suppl.1,p.49-54
NICHOL, A.W. et al.,Biochemistry,1967年 4月,Vol.6/No.4,P1008-1014
GROMOVA, E.S. et al.,Biochimica et Biophysica Acta,1971年,Vol.240,p.1-11
SOKOLOVA,N.I. et al,Nucleotide-peptide bonding in derivatives of guanosine 5'-monophosphate and inosine 5'-monophosphate,Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D. I. Mendeleeva,1969年,Vol.14, No.5,p.583-4
WASSERMAN,H.H. et al,Phosphorylating agents by the activation of phosphates with ethoxyacetylene,Journal of Organic Chemistry,1964年,Vol.29, No.7,p.1817-20
HADDEN, J.W. et al.,International Journal of Immunopharmacology,Pergamon Press Ltd.,1992年,Vol.14/No.4,p.555-563
SOSA, M. et al.,Annals of the New York Academy of Sciences,米国,1993年,Vol.685 (Immunomodulating Drugs),p.458-463
HADDEN, J.W. et al.,International Journal of Immunopharmacology,Pergamon Press plc.,1991年,Vol.13/suppl.1,p.49-54
NICHOL, A.W. et al.,Biochemistry,1967年 4月,Vol.6/No.4,P1008-1014
GROMOVA, E.S. et al.,Biochimica et Biophysica Acta,1971年,Vol.240,p.1-11
SOKOLOVA,N.I. et al,Nucleotide-peptide bonding in derivatives of guanosine 5'-monophosphate and inosine 5'-monophosphate,Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D. I. Mendeleeva,1969年,Vol.14, No.5,p.583-4
WASSERMAN,H.H. et al,Phosphorylating agents by the activation of phosphates with ethoxyacetylene,Journal of Organic Chemistry,1964年,Vol.29, No.7,p.1817-20
Attorney, Agent or Firm:
Hidesaku Yamamoto