Title:
6-(1-HYDROXYETHYL) -2-SR8-1-METHYL-1-CARBADETHIAPEN-2-EM-3-CARBOXYL ACID ESTER
Document Type and Number:
Japanese Patent JPS59130884
Kind Code:
A
Abstract:
Disclosed are 6-[1-hydroxyethyl]-2-SR<8>-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters (I) which are orally active antibiotics: wherein: R is a pharmaceutically acceptable ester moiety consistent with oral delivery; and R<8> is substituted or unsubstituted: alkyl, alkenyl, alkynyl, or cyclic alkyl, alkenyl, alkynyl, having 1-6 carbon atoms, aryl such as phenyl or heteroaryl such as pyridyl; wherein the substituent or substituents are selected from: phenyl, pyridyl, cyano, fluoro, chloro, hydroxy, alkylthio such as methylthio, arylthio such as phenylthio, methoxy, phenoxy, alkoxycarbonyl such as methoxycarbonyl, acetoxyl, N-methylcarbamoyl, N-methylcarbamoyloxy and N-acylamino. Also disclosed are processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds.
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Inventors:
BAATON JII KURISUTENSEN
DEIBUITSUDO ETSUCHI SHIII
DEIBUITSUDO ETSUCHI SHIII
Application Number:
JP24501683A
Publication Date:
July 27, 1984
Filing Date:
December 27, 1983
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07D477/00; A61K31/397; A61K31/40; A61P31/04; C07C205/42; C07D205/08; C07D405/14; C07D477/20; C07D498/04; C07F7/10; C07F7/18; C07F9/6561; (IPC1-7): A61K31/40; A61K31/44; A61K31/54; C07D487/04
Attorney, Agent or Firm:
Masao Okabe
Previous Patent: JPS59130883
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