Title:
6-O-METHYLERYTHROMYCIN A OXIME DERIVATIVE
Document Type and Number:
Japanese Patent JPH03204893
Kind Code:
A
Abstract:
NEW MATERIAL:A compound of the formula (X is benzyl whose benzene ring is substituted with 1-5 halogen atoms, phenyl substituted with 1-3 nitro groups, α-methylbenzyl, α-methylphenetyl, diphenylmethyl, trityl, dibenzosuberanyl, etc.; Y is H, nitro-substituted phenyl or 2-aminothiazol-4-ylmethylcarbonyl).
EXAMPLE: 6-O-Methylerythromycin A 9-[O-(2,4,6-trimethylbenzyl)oxime].
USE: An antibiotic exhibiting a strong antibacterial activity against erythromycin- resistant bacteria.
PREPARATION: 6-O-Methylerythromycin A 9-oxime is dissolved in an organic solvent and subsequently reacted with a compound of formula: X-Z (Z is halogen) in the presence of a base.
Inventors:
MISAWA YOKO
ASAGA TOSHIBUMI
KASHIMURA MASATO
MORIMOTO SHIGEO
WATANABE YOSHIAKI
HATAYAMA KATSUO
ASAGA TOSHIBUMI
KASHIMURA MASATO
MORIMOTO SHIGEO
WATANABE YOSHIAKI
HATAYAMA KATSUO
Application Number:
JP26581290A
Publication Date:
September 06, 1991
Filing Date:
October 03, 1990
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61K31/70; A61K31/7042; A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): A61K31/71; C07H17/08
Attorney, Agent or Firm:
Tomizo Kitagawa
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