Title:
6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS SELECTIVE ER-β AGONISTS
Document Type and Number:
Japanese Patent JP2016138113
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide novel 6-substituted 13-demethyl-estradiol derivatives as selective ER-β agonists and analgesic agents comprising the same.SOLUTION: There is provided a 6-substituted 13-demethyl-estradiol compound represented by the following formula, where X is methoxymethyl group, 6-methoxyhexyl group, hydroxymethyl group, (aminooxy)methyl group, (methoxymethyl)amino group, methoxy group, 2-methoxyethyl group, 4-methoxybutyl group etc.; R-Rare independently H, alkyl, halogen, a sulfate, hydroxyl, aryl, cycloalkyl, heteroaryl, a phosphate group etc.; Ris H, alkyl, a glucuronide, COOH, CN, CHO etc.SELECTED DRAWING: None
Inventors:
JAMES G YARGER
STEVEN H NYE
STEVEN H NYE
Application Number:
JP2016030043A
Publication Date:
August 04, 2016
Filing Date:
February 19, 2016
Export Citation:
Assignee:
ENDECE LLC
International Classes:
C07J1/00; A61K31/565; A61P25/04; A61P43/00
Domestic Patent References:
| JP5981434B2 | 2016-08-31 |
Foreign References:
| US20100130463A1 | 2010-05-27 |
Other References:
JPN6015041612; ＳＰＯＯＮＥＲ Ｍ．Ｆ． ｅｔ ａｌ．: Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．１５０, 2007, ｐ．６７５-８０
Attorney, Agent or Firm:
Hatta International Patent Corporation
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