Title:
6,7-不飽和-7-カルバモイル置換モルヒナン誘導体
Document Type and Number:
Japanese Patent JP4323547
Kind Code:
B2
Abstract:
A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I):
wherein R 1 and R 2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., R 3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., R 4 is hydrogen or lower alkyl, R 5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl,
or a pharmaceutically acceptably salt, or a solvate thereof is provided.
Inventors:
Masahisa Inagaki
Shinichiro Hara
Nobuhiro Haga
Yoshinori Tamura
Yoshihisa Goto
Go Hasegawa
Shinichiro Hara
Nobuhiro Haga
Yoshinori Tamura
Yoshihisa Goto
Go Hasegawa
Application Number:
JP2007517895A
Publication Date:
September 02, 2009
Filing Date:
May 25, 2006
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D489/08; A61K31/485; A61K31/5377; A61P1/08; A61P1/10; A61P25/04; A61P43/00; C07D489/09
Domestic Patent References:
| JP2003528819A | ||||
| JP2004501094A | ||||
| JP2004522706A |
Foreign References:
| WO2002042309A1 | ||||
| WO2004005294A1 |
Other References:
Hideaki Fujii et al.,The First Example of the Stereoselective Synthesis of 7β-Carbamoyl-4,5α-epoxymorphinan via a Novel and Reactive γ-Lactone,Chemical and Pharmaceutical Bulletin,2004年,Vol.52, No.6,p.747-750
Attorney, Agent or Firm:
Kenichi Sugita
Hiromitsu Takayama
Hiromitsu Takayama