ケモカイン関連疾患の処置のための7-アミノ-2-アルキルチオプテリジン-4-イルアミン

Japanese Patent JP4250416

B2

Pteridine compounds of formula (I) processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in the treatment of inflammatory diseases such as psoriasis, rheumatoid arthritis, diseases in which angiogenesis is assocated with raised CXCR2 chemokine levels (diabetic retinopathy) and COPD. The compounds are ligands for chemokine receptors and medical indications mentioned in the description include: diseases of the respiratory tract (COPDD, asthma, bronchitis, rhinitis, fibroid lung, pneumonia, etc.), diseases of the bones and joints (arthritis, etc.), skin-diseases (psoriasis, etc), diseases of the gastrointestinal tract, diseases in other tissues and systemic disease (multipe sclerosis, atherosclerosis, AIDS, type 1 diabetes, leprosy, sepsis, etc.), allograft rejection, cancers, cystic fibrosis, stroke, burn wounds, skin ulcers, reproductive disease and more.

Roger Bonato
Ian Walters

JP2002535743A

April 08, 2009

October 16, 2001

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ASTRAZENECA AKTIEBOLAG

C07D475/06; A61K31/519; A61P1/04; A61P3/10; A61P11/00; A61P17/06; A61P25/00; A61P29/00; A61P35/00

GB1009477B

Joseph Weinstock et al.,Pteridines. XII. Structure-Activity Relationships of Some Pteridine Diuretics,Journal of Medicinal Chemistry,1968年,Vol.11, No.3,p.573-579
R. G. W. Spickett et al.,The Synthesis of Compounds with Potential Anti-folic Acid Activity. Part I. 7-Amino- and 7-Hydroxy-pteridines,Journal of the Chemical Society,1954年,p.2887-2895

Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima

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