Title:
7-OXO-2,1,4-OXATHIAZEPINO- 4,3-B ISOQUINOLINE-2,2-DIOXIDE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS55124791
Kind Code:
A
Abstract:
NEW MATERIAL:The title derivative of formula I [R1 is H, halogen, nitro, amino, lower alkyl(amino) group, etc.; R2 is lower alkyl group].
EXAMPLE: 12-Methyl-7-oxo-3H, 7H -4, 5-dihydro-2, 1, 4-oxathiazepino[4,3-b]-isoquinoline-2, 2-dioxide.
USE: Analgesics, antiphlogistics, muscle relaxants, phatelet aggregation inhibitors, antimicrobials, central nervous system depressants, and an intermediate for other drugs.
PROCESS: A compound of formula II is heated, preferably molten, or heated in an organic solvent, e.g. acetic acid, under refluxing to rearrange the sulfonyl group.
Inventors:
KUBO KAZUO
ITOU TOKUKI
ISOMURA YASUO
ITOU TOKUKI
ISOMURA YASUO
Application Number:
JP3211079A
Publication Date:
September 26, 1980
Filing Date:
March 19, 1979
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD
International Classes:
C07D515/04; A61K31/54; A61P7/02; A61P25/00; A61P25/04; A61P29/00; A61P31/04; (IPC1-7): A61K31/54; C07D515/04