NEW MATERIAL:A compound shown by the formula I (R1 is H, 1W10C alkyl, substituted or unsubstituted phenyl, etc.; R2 and R3 are H, tri 1W7C hydrocarbonsilyl, etc.; R4 is H, methyl, or vinyl; R5 is 3W6C alkyl which may contain O, phenyl, phenoxy, etc. which may be substituted; X is ethynylene, cis-vinylene, etc. n is 0 or 1) its epimer (n=1) or its enantiomer or its mixture.
EXAMPLE: 4,4,5,5-Dehydro-7-thiaprostaglandin E1.
USE: Having an inhibitory action on blood platelet aggregation, vasodilating action, antihypertensive action, and useful as a preventive and a remedy for thrombosis, an inhibitor of blood platelet aggregation, a hypotensor, etc.
PREPARATION: A compound shown by the formula II (R11 is 1W10C alkyl, etc.; R21 is tri 1W7C sivyl, etc.) a compound shown by the formula (III R31 is tri 1W7C silyl, tc.), and an organocopper compound obtained from a copper compound shown by the formula CuQ (Q is halogen, etc.) are subjected to conjugated addition reaction, to give a compound shown by the formula I.
SAKAUCHI KIYOSHI
KUROZUMI SEIJI
