Title:
77 HIDOROKISHIIESUTORAJIOORUNOSEIHO
Document Type and Number:
Japanese Patent JPS5165747
Kind Code:
A
Abstract:
1528796 7α-Hydroxy-cotradiols SCHERING AG 13 Oct 1975 [14 Oct 1974 8 Aug 1975] 41798/75 Heading C2U Novel steroids of the formula (wherein R 1 is H, acyl, optionally substituted alkyl, cycloalkyl or a saturated oxygen-containing heterocyclic group; R 2 and R 3 are each H, acyl or a saturated oxygen-containing heterocyclic group; and R 4 is a C 1-5 aliphatic hydrocarbon group which may be chloro-substituted if it is unsaturated) are prepared from the corresponding 17-ones and suitable reagents containing R 4 . They may also be obtained by microbiological hydroxylation of the corresponding 7-unsubstituted-17#-ols. In the products OH groups may be esterified or etherified and esters and ethers may be hydrolysed. 3,7α - bis - tetrahydropyranyloxy - #1,3,5(10) - estratrien-17-one is prepared from the corresponding 3,7-diol and dihydropyran. 3-Cyclopentyloxy - 7α - hydroxy - #1,3,5(10) -estratrien - 17- one is prepared from the same starting material and cyclopentyl bromide. The novel steroids possess a strong vaginotropic and a weak uterotropic action and they are suitable for treatment of estrogen deficiency phenomena, particularly for postmenopausal treatment of women. They may be made up into pharmaceutical compositions with suitable carriers.
Inventors:
KAARU PETSUORUTO
HANSU IERUKU FUIDEIKU
KURAUSU PURETSUEUOFUSUKII
YUKISHIGE NISHINO
RUUDORUFU UIIHIERUTO
HENRII ROORENTO
HANSU IERUKU FUIDEIKU
KURAUSU PURETSUEUOFUSUKII
YUKISHIGE NISHINO
RUUDORUFU UIIHIERUTO
HENRII ROORENTO
Application Number:
JP12374375A
Publication Date:
June 07, 1976
Filing Date:
October 14, 1975
Export Citation:
Assignee:
SCHERING AG
International Classes:
A61K31/565; C07J1/00; C07J11/00; C07J17/00; C07J31/00; (IPC1-7): A61K31/565; C07J1/00