7ALPHA-ALKYL-17ALPHA-PREGN-4-ENE-21,17- CARBOLACTONE AND -21-CARBOXYLATE, MANUFACTURE AND ANTIALDOSTERONIC PHARMACEUTIC-AL MEDICINE

Title:

7ALPHA-ALKYL-17ALPHA-PREGN-4-ENE-21,17- CARBOLACTONE AND -21-CARBOXYLATE, MANUFACTURE AND ANTIALDOSTERONIC PHARMACEUTIC-AL MEDICINE

Document Type and Number:

Japanese Patent JPS5970700

Kind Code:

A

Abstract:

7 alpha -substituted-17 alpha -pregn-4-ene-21, 17-carbolactones and -21-carboxylic acid salts of formula I. wherein C1@@@C2 is a C-C single or C=C double bond, R is a saturated or unsaturated, straight-chain or branched aliphatic radical of 1-6 carbon atoms, optionally substituted by a chlorine atom or a hydroxy group, and wherein M is an alkali metal, (e.g., Na, K), preferably potassium exhibit a strong antialdosterone effect and only a very slight antiandrogenic side effect.

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Inventors:

KURAUSU NIKISHIYU
DEIITAA BITSUTORAA
HENRII RAURENTO
RUDORUFU BUIIHIERUTO
BUORUFUGANGU ROOZERUTO

Application Number:

JP16268383A

Publication Date:

April 21, 1984

Filing Date:

September 06, 1983

Export Citation:

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Assignee:

SCHERING AG

International Classes:

C07J1/00; A61K31/565; A61K31/585; A61P13/02; A61P15/00; C07J21/00; C07J53/00; (IPC1-7): A61K31/565; A61K31/585; C07J1/00; C07J21/00

Attorney, Agent or Firm:

Toshio Yano

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