Title:
8-[{1-(3,5-ビス-(トリフルオロメチル)フェニル)-エトキシ}メチル]-8-フェニル-1,7-ジアザ-スピロ[4.5]デカン-2-オン化合物の合成のための方法および中間体
Document Type and Number:
Japanese Patent JP5451404
Kind Code:
B2
Abstract:
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations.
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Inventors:
Melgelsberg, Ingrid
Scheller, Dominic Harman
Hatten Rosh, Erica Monica
Tsui, Hong-Chun
Pariwar, Sneal
See, Nen-Yang
Scheller, Dominic Harman
Hatten Rosh, Erica Monica
Tsui, Hong-Chun
Pariwar, Sneal
See, Nen-Yang
Application Number:
JP2009554566A
Publication Date:
March 26, 2014
Filing Date:
March 20, 2008
Export Citation:
Assignee:
Opco Health, Incorporated
International Classes:
C07D471/10; A61K31/438; A61P1/08; A61P25/04; A61P25/06; A61P29/00; A61P43/00; C07D211/38; C07D498/10; C07B53/00; C07B61/00
Domestic Patent References:
| JP2010522173A | ||||
| JP2005513068A | ||||
| JP2009532472A | ||||
| JP2006524251A |
Foreign References:
| WO2006065654A1 | ||||
| WO2006007540A1 | ||||
| US3094522 | ||||
| WO2005100358A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita