8-SUBSTITUTED-1,3,8-TRIAZE-SPIRO(4,5)DECAN-4-ONE DERIVATIVE

Japanese Patent JP3292457

B2

PROBLEM TO BE SOLVED: To obtain the subject new compound which is an agonist for OFQ receptor and/or an antagonist useful for treating mental disturbance, nervous disturbance and physiological disorder.
SOLUTION: This compound is shown by formula I (R1 and R2 are each H, a lower alkyl, etc.; R3 is phenyl; R4 is H, a lower alkyl, an acyl, etc.; R5 and R6 are each H, a lower alkyl, etc., or bonded together to form a phenyl ring; R5 and one of R1 and R2 can be bonded to form a 6-memered ring; A is a saturated 4- to 7-membered ring containing a hetero atom such as O or S) or its acid addition salt such as 8-(8-chloro-1,2,3,4,-tetrahydro-naphthyl-2)-1- phenyl-1,3,8-triaza-spiro[4,5]decan-4-one. The compound of formula I is obtained by hydrogenating a double bond in a compound of formula II (A' is a 5 to 7-membered ring containing a hetero atom such as O or S). The compound is useful for treating anxiety, stress disorder, depression, traumatic disorder, amnesia caused by Alzheimer's disease or other dementia, epilepsy and convulsion.

Geo Adam
Andrea Cessla
Gweed Galei
Francois Genk
Frederick Monsuma
Stephan Laver
Jürgen Wichmann

JP1371198A

June 17, 2002

January 27, 1998

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F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

A61K31/41; A61K31/435; A61K31/438; A61K31/445; A61K31/55; A61K51/02; A61P3/04; A61P3/12; A61P9/00; A61P9/12; A61P25/00; C07D233/04; A61P25/04; A61P25/08; A61P25/18; A61P25/20; A61P25/24; A61P25/26; A61P25/28; A61P25/30; A61P43/00; C07D215/58; C07D305/14; C07D471/00; C07D471/10; C07D498/00; A61K31/00; (IPC1-7): C07D471/10

JP1153662A
JP5212171A
JP59139384A

Hajime Tsukuni (1 person outside)

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