Title:
9,10-α,α-OH-タキサンアナログおよびその生成のための方法
Document Type and Number:
Japanese Patent JP5525394
Kind Code:
B2
Abstract:
The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R 1 and R 2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R 3 is hydroxyl or OP 1 ; R 4 and R 5 are each hydroxyl or R 7 COO; R 6 is hydroxyl, OP 2 , R 7 COO, or an ether functionally; R 7 is an alkyl group, an olefinic group, or an aromatic group; and P 1 and P 2 are each hydroxyl protecting groups. The chemical compounds of the present invention may particularly be 9, 10-±,±-OH taxane analogs that are formed by a process that begins with a standard taxane as the starting compound.
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Inventors:
James Dee.Matchesney
James Ferrara
Jean Sigmund
James Ferrara
Jean Sigmund
Application Number:
JP2010200399A
Publication Date:
June 18, 2014
Filing Date:
September 07, 2010
Export Citation:
Assignee:
Tapestry Pharmaceuticals, Inc.
International Classes:
C07D305/14; A61K31/337; C07D405/02; C07D493/04; C07D493/08; A61K31/357; A61P35/00; A61K
Domestic Patent References:
| JP7505887A |
Other References:
J. Org. Chem.,1998年,Vol.63, No.24,p.8926-8934
Tetrahedron Lett.,1995年,Vol.36, No.12,p.1985-1988
J. Med. Chem.,1995年,Vol.38, No.9,p.1482-1492
Tetrahedron Lett.,1995年,Vol.36, No.12,p.1985-1988
J. Med. Chem.,1995年,Vol.38, No.9,p.1482-1492
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita