Title:
異所性脂肪蓄積治療用Ａ３アデノシン受容体リガンド
Document Type and Number:
Japanese Patent JP6990934
Kind Code:
B2
Abstract:
Provided is an A3AR ligand for reducing ectopic fat accumulation, particularly in fatty liver. Further provided is the use of A3AR ligand for the preparation of a pharmaceutical composition for reducing such fat accumulation, method of treating a condition associates with fat accumulation making use of the ligand and kits including pharmaceutical compositions including the ligand, and instructions for use of same, for treating a condition associated with ectopic fat accumulation. Further provided is the use of an A3AR agonist, such as 2-Chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide (CI-IB-MECA, CF102) for treating fatty liver, specifically, non-alcoholic fatty liver disease (NAFLD).
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Inventors:
Fish man, punina
Cohen
Cohen
Application Number:
JP2020020917A
Publication Date:
January 12, 2022
Filing Date:
February 10, 2020
Export Citation:
Assignee:
Can-Fite BioPharma Ltd.
International Classes:
A61K31/7076; A61P1/16; A61P3/04
Foreign References:
| WO2013111132A1 |
Other References:
GOODMAN, Zachary D.,Journal of Hepatology,2007年,Vol 47, Issue 4,pp. 598-607,https://doi.org/10.1016/j.jhep.2007.07.006
European Journal of Cancer,2010年,Supplements,p.122,384 POSTER
JOURNAL OF CELLULAR PHYSIOLOGY,2011年,226,p.2438-2447
CHOI HA-NEUL,CORDYCEPS MILITARIS ALLEVIATES NON-ALCOHOLIC FATTY LIVER DISEASE IN OB/OB MICE,NUTRITION RESEARCH AND PRACTICE,2014年04月,VOL:8, NR:2,PAGE(S):172 - 176,http://dx.doi.org/10.4162/nrp.2014.8.2.172
European Journal of Cancer,2010年,Supplements,p.122,384 POSTER
JOURNAL OF CELLULAR PHYSIOLOGY,2011年,226,p.2438-2447
CHOI HA-NEUL,CORDYCEPS MILITARIS ALLEVIATES NON-ALCOHOLIC FATTY LIVER DISEASE IN OB/OB MICE,NUTRITION RESEARCH AND PRACTICE,2014年04月,VOL:8, NR:2,PAGE(S):172 - 176,http://dx.doi.org/10.4162/nrp.2014.8.2.172
Attorney, Agent or Firm:
Patent business corporation Kita Aoyama International