Title:
神経系の細胞へのDNAのAAV仲介送達
Document Type and Number:
Japanese Patent JP4843663
Kind Code:
B2
Abstract:
The invention relates to a method of delivering exogenous DNA to a target cell of the mammalian central nervous system using an adeno-associated virus (AAV)-derived vector. Also included in the invention are the AAV-derived vectors containing exogenous DNA which encodes a protein or proteins which prevent or treat nervous system disease, and a method of prevent or treating such disease.
Inventors:
Caprice Michael G
Darling matthew jay
Darling matthew jay
Application Number:
JP2008301501A
Publication Date:
December 21, 2011
Filing Date:
November 26, 2008
Export Citation:
Assignee:
The Rockefeller University
Yale University
Yale University
International Classes:
C12N15/09; A61K31/711; A61K35/76; A61K38/00; A61K38/18; A61K38/44; A61K38/46; A61K38/51; A61K48/00; A61P25/00; A61P25/08; A61P25/16; A61P25/28; A61P35/00; C07K14/48; C12N9/02; C12N9/88; C12N15/864; C12R1/91
Foreign References:
| US5212082 |
Other References:
Advanced Drug Delivery Reviews,Vol.12,No.3(1993)p.201-215
Neurology,Vol.44,4 Suppl.2(1994.Apr.)p.A163
Biochem.Biophys.Res.Commun.,Vol.164,No.3(1989)p.1024-1030
Nat.Genet.,Vol.8,No.2(1994.Oct.)p.148-154
Neurology,Vol.44,4 Suppl.2(1994.Apr.)p.A163
Biochem.Biophys.Res.Commun.,Vol.164,No.3(1989)p.1024-1030
Nat.Genet.,Vol.8,No.2(1994.Oct.)p.148-154
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Nobuo Ogawa
Fumiaki Otsuka
Nobuo Ogawa