Title:
ＡＧＥ由来メラニン産生方法及び組成物
Document Type and Number:
Japanese Patent JP7069270
Kind Code:
B2
Abstract:
To provide a composition and a method for directly producing melanin without activating tyrosinase.SOLUTION: There are provided: a composition for producing AGE-derived melanin which consists of AGE-modified collagen in which collagen is glycated; and an AGE-derived melanin-producing agent comprising the composition. The composition comprises methylglyoxal, glyoxal, or 3-deoxyglucosone. There is also provided an AGE-derived melanin production method that comprises administering AGE-modified collagen to a subject. Preferably, the saccharification is due to monosaccharides. The monosaccharides include at least glucose (dextrose), galactose, mannose, and fructose. Glucose and fructose are preferable as the monosaccharide for saccharification, but glucose is particularly preferable. Since the composition and the method are useful for acquiring melanin produced by a new mechanism, they are also useful for the development of a new material.SELECTED DRAWING: None
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Inventors:
Tomomi Abe
Fumiyuki Isamu
Fumiyuki Isamu
Application Number:
JP2020172284A
Publication Date:
May 17, 2022
Filing Date:
October 13, 2020
Export Citation:
Assignee:
Morinda, Inc.
International Classes:
C07K14/78; A61K8/65; A61K38/39; A61P43/00
Domestic Patent References:
| JP7109215A | ||||
| JP2000350778A | ||||
| JP2014140423A |
Other References:
「表皮細胞」の糖化がシミの発生に関係する可能性を解明,ロート製薬株式会社[online],2015年02月04日,URL: https://www.rohto.co.jp/news/release/2015/0204_01/,[retrieved on 10.13.2021]
Ishibashi, M. et al.,Glycation Stress and Photo-Aging in Skin,ANTI-AGING MEDICINE,2011年,Vol. 8,pp. 23-29
奥山健二,コラーゲンの構造,日本結晶学会誌,2012年,Vol. 54(5),pp. 263-269
Ishibashi, M. et al.,Glycation Stress and Photo-Aging in Skin,ANTI-AGING MEDICINE,2011年,Vol. 8,pp. 23-29
奥山健二,コラーゲンの構造,日本結晶学会誌,2012年,Vol. 54(5),pp. 263-269
Attorney, Agent or Firm:
Takahashi Go
Masakazu Takahashi
Tomokazu Takahashi
Masakazu Takahashi
Tomokazu Takahashi