ANTIBODY TO MAdCAM

Japanese Patent JP2009005695

A

To provide a therapy method associated with a MAdCAM (mucosal addressin cell adhesion molecule) to an inflammatory intestinal disease.

The antibody includes a human antibodies and an antigen-binding portion thereof that specifically binds to human MAdCAM and that functions to inhibit MAdCAM. The human anti-MAdCAM antibody and an antigen-binding portion thereof are provided. The antibody that is chimeric, bispecific, derivatized, a single strand antibody or a portion of a fusion protein is provided. The isolated heavy and light chain immunoglobulin derived from human anti-MAdCAM antibody and the nucleic acid molecule encoding such an immunoglobulin are provided. A method of making a human anti-MAdCAM antibody and a compositions comprising the antibody and a method of using the antibody and the composition for diagnosis and treatment are provided. A gene therapy method uses a nucleic acid molecule encoding the heavy and/or light chain immunoglobulin molecule that comprise the human anti-MAdCAM antibody.

PULLEN NICHOLAS
MOLLOY ELIZABETH
KELLERMANN SIRID-AIMEE
GREEN LARRY L
HAAK-FRENDSCHO MARY

JP2008149091A

January 15, 2009

June 06, 2008

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PFIZER
AMGEN FREMONT INC

C12N15/09; A01H5/00; A01K67/027; A61K31/711; A61K39/00; A61K39/395; A61K48/00; A61P1/02; A61P1/04; A61P1/12; A61P1/16; A61P1/18; A61P3/02; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P13/10; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/14; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K16/28; C12N5/06; C12N5/10; C12N15/02; C12P21/00; C12P21/08; C12Q1/02; G01N33/53; G01N33/577; C07K14/705

JP2003531129A	2003-10-21
JP2002514660A	2002-05-21

Hatsushi Shimizu
Koichi Niimi

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