癌治療用のＡＸＬ特異的抗体－薬物コンジュゲート

Title:

癌治療用のＡＸＬ特異的抗体－薬物コンジュゲート

Document Type and Number:

Japanese Patent JP7428680

Kind Code:

B2

Abstract:

The present invention relates to antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of resistant or refractory cancers.

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Inventors:

Boschuisen Julia
jacobsen kristin
Bray ester
Coupman Louise
Satin David
Van den Brink Edward
Ferzier Dennis
De Jong Grob
Van Dijkhausen Radelsma Reemke
Peeper Daniel
Ditzel Henrik Jorn
Palen Paul

Application Number:

JP2021088877A

Publication Date:

February 06, 2024

Filing Date:

May 27, 2021

Export Citation:

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Assignee:

GENMAB A/S

International Classes:

A61K47/68; A61K38/07; A61K39/395; A61P35/00; A61P35/02; A61P43/00

Domestic Patent References:

JP2011505120A

Foreign References:

WO2014174111A1
WO2012175691A1
WO2012175692A1

Other References:

nature communications,2014年,Vol.5:5712,pp.1-15,DOI: 10.1038/ncomms6712
Esther C.W. Breij, et al.,Novel antibody-drug conjugates targeting Axl show anti-tumor activity in solid cancer xenograft mode,American Association for Cancer Research,2015年04月18日,p.1-2
NATURE,2010年,Vol.468,pp.973-977, METHODS

Attorney, Agent or Firm:

Hatsushi Shimizu
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto

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