Title:
セリンプロテアーゼ阻害剤として有用な酸誘導体
Document Type and Number:
Japanese Patent JP2004514669
Kind Code:
A
Abstract:
Compounds having the formula (I),are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, IXa, Xa, and/or XIa, wherein ring B is phenyl or pyridyl, W is preferably C(=O)NR4R5, L is a linker group, X2 comprises nitrogen or carbon, Z is an optionally-substituted monocyclic or bicyclic ring system, and R1, R2, R3, R4, R5 and R6 are as defined in the specification.
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Inventors:
Besatch, Gregory S
Sutton, James Sea Junior
Sully Sark, William A.
Trüner, You Wedi
Zao, Guofa
Cheney, Danielle
Woo, shansea
Sea, Yang
Sutton, James Sea Junior
Sully Sark, William A.
Trüner, You Wedi
Zao, Guofa
Cheney, Danielle
Woo, shansea
Sea, Yang
Application Number:
JP2002544409A
Publication Date:
May 20, 2004
Filing Date:
November 07, 2001
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/166; A61K31/341; A61K31/343; A61K31/381; A61K31/4035; A61K31/404; A61K31/4045; A61K31/4184; A61K31/421; A61K31/423; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4418; A61K31/443; A61K31/4433; A61K31/4439; A61K31/444; A61K31/445; A61K31/4462; A61K31/4465; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/506; A61K31/517; A61K31/55; A61K45/00; A61K45/06; A61P1/04; A61P1/16; A61P1/18; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P37/08; A61P43/00; C07C233/78; C07C257/18; C07D207/16; C07D209/08; C07D209/44; C07D211/26; C07D211/60; C07D213/73; C07D213/81; C07D223/06; C07D235/08; C07D235/30; C07D261/20; C07D263/32; C07D277/20; C07D277/40; C07D277/82; C07D307/68; C07D307/79; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/10; C07D405/12; C07D405/14; C07D409/12; C07D333/38; C07D409/14; C07D417/12; C07D471/04; (IPC1-7): C07C233/78; A61K31/166; A61K31/341; A61K31/343; A61K31/381; A61K31/4035; A61K31/404; A61K31/4045; A61K31/4184; A61K31/421; A61K31/423; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4418; A61K31/443; A61K31/4433; A61K31/4439; A61K31/444; A61K31/445; A61K31/4462; A61K31/4465; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/506; A61K31/517; A61K31/55; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P37/08; A61P43/00; C07D209/08; C07D209/44; C07D211/26; C07D213/73; C07D213/81; C07D235/08; C07D235/30; C07D261/20; C07D263/32; C07D277/20; C07D277/40; C07D277/82; C07D307/68; C07D307/79; C07D333/38; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/10; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D417/12; C07D471/04
Attorney, Agent or Firm:
Takehiko Saito
Yasuyuki Hata
Yasuyuki Hata