酸感受性化合物、該化合物の製造および使用

Title:

酸感受性化合物、該化合物の製造および使用

Document Type and Number:

Japanese Patent JP2004508364

Kind Code:

A

Abstract:

Novel acid-sensitive compounds comprising at least one hydrophilic substituent and a cyclic ortho-ester which is acid-sensitive, and their salts. These compounds are useful for forming conjugates (liposomes, complexes, nanoparticles and the like) with biologically active substances and releasing them into cellular tissues or compartments whose pH is acidic, or as nonionic surfactant for stabilizing particles encapsulating a biologically active substance and then destabilizing them in acid medium, or alternatively as a vector covalently linked to a therapeutic molecule so as to release said therapeutic molecule into the cellular tissues or compartments whose pH is acidic.

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Inventors:

Beth Sword, Michelle
Mason, Christoph
Daniel Cielman
Wetzel, Barbara

Application Number:

JP2002525131A

Publication Date:

March 18, 2004

Filing Date:

September 03, 2001

Export Citation:

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Assignee:

The Jansell S Are

International Classes:

A61K9/127; A61K47/48; A61P9/10; C07D317/34; C07D319/06; C07J41/00; C12N15/09; (IPC1-7): C07D317/34; A61K9/127; A61K47/48; C07D319/06; C12N15/09

Attorney, Agent or Firm:

Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki

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