酸感受性ポリアセタールおよび製造方法

Japanese Patent JP4809768

B2

Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II): wherein A comprises at least one acetal group; B is selected from the group consisting of -CH-, -CH(CH₃)-, CH₂CH-, -CH₂C(CH₃)-, -CH(CH₃)CH-, and -CHCH(CH₃)CH(CH₃)-; Z is selected from the group consisting of C(O)OR¹, C(O)SR¹, C(O)NR¹R², and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; R¹ and R² are each individually selected from the group consisting of hydrogen, C₁ to C₁₀ alkyl, and C₆ to C₁₀ aryl; D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and G is selected from the group consisting of C₄ to C₂₀ alkyl, C₆-C₁₀ aryl, and -(OCH₂CH₂)_n-, where n is in the range of 1 to about 250, are useful in nucleic acid delivery applications. In preferred embodiments, complexes formed between polyacetals of the formulae (I) or (II) and polynucleotides are useful as transfection reagents.

Van, Sun
Bilone Chattapan, Nitonara
Ji, Shoupin
Yu, Ray

JP2006524662A

November 09, 2011

July 28, 2004

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NITTO DENKO CORPORATION

C08G85/00; A61K31/7088; A61K38/00; A61K39/395; A61K47/34; A61K48/00; C07C219/06; C07C219/14; C07C229/22; C07C231/12; C08G4/00; C08G18/32; C08G73/02; C08G81/00

WO2004076557A1	2004-09-10
WO2002020633A1	2002-03-14

Patent Business Corporation Unias International Patent Office
Koichi Kajisaki
Yuzo Ozaki
Toshihiko Taniguchi

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