Title:
活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
Document Type and Number:
Japanese Patent JP6529952
Kind Code:
B2
Abstract:
The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an "activatable" conformation such that at least one of the TMBs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Inventors:
Dougerty, patrick, scene
Stagliano, Nancy, E.
Thomas, Jerry
Kamas, Kathryn
West, James, W
Calle, Sanjay
Saggart, jason
Stagliano, Nancy, E.
Thomas, Jerry
Kamas, Kathryn
West, James, W
Calle, Sanjay
Saggart, jason
Application Number:
JP2016233739A
Publication Date:
June 12, 2019
Filing Date:
December 01, 2016
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C12N15/62; A61K38/16; A61P35/00; A61P43/00; C07K16/18; C07K16/22; C07K16/24; C07K19/00; C12P21/02; C12Q1/37; C40B40/10; G01N33/50; G01N33/566
Domestic Patent References:
| JP2006506333A | ||||
| JP2006503545A | ||||
| JP2001511111A |
Foreign References:
| WO2004027045A1 |
Other References:
Mol. Pharm.,2004年,Vol.1, No.1,pp.9-22
Cell Death Differ.,2007年 4月,Vol.14, No.4,pp.765-774
Cell Death Differ.,2007年 4月,Vol.14, No.4,pp.765-774
Attorney, Agent or Firm:
Naoto Uchida