活性なシルク粘液接着剤、シルク電気的ゲル化方法、およびデバイス

Japanese Patent JP5885505

B2

The present invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to ²-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for a variety of medical applications. The electrogelated silk exists as a piezoelectric silk material comprising a mixture of silk fibroin proteins having silk I conformation and silk ²-sheet structure. Silk electrogelation process of the present invention is useful in variety of applications such as tissue engineering, medical device or implants, drug delivery, soft robotics or motion associated technology.

Bernhard Nikolai N.
Rotim Cha-Ching
Raysk Gary Gee.
Kaplan David L.

JP2011529298A

March 15, 2016

September 28, 2009

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Tufts University/Trusties of Tufts College

C07K14/435; A61B17/28; A61C8/00; A61F2/00; A61F2/06; A61K6/00; A61K6/884; A61K9/06; A61K38/17; A61K47/42; A61L15/16; A61L17/00; A61L27/00; A61L31/00; A61L33/00; A61P17/02; C08J3/075

JP4263611A
JP2008502739A
JP2007515391A

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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