Title:
ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Document Type and Number:
Japanese Patent JP2022031744
Kind Code:
A
Abstract:
To provide activity-based probe compounds for use in labeling a cysteine protease.SOLUTION: The compounds are targeted to protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.SELECTED DRAWING: None
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Inventors:
MATTHEW S BOGYO
MARTIJN VERDOES
MARTIJN VERDOES
Application Number:
JP2021186871A
Publication Date:
February 22, 2022
Filing Date:
November 17, 2021
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR
International Classes:
C07D209/60; A61K49/00; G01N33/53; G01N33/68
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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