Title:
非環式リンカー含有オリゴヌクレオチド及びその用途
Document Type and Number:
Japanese Patent JP2005508634
Kind Code:
A
Abstract:
Oligonucleotides having an internal acyclic linker residue, and the preparation and uses thereof, are described. Such uses include the preparation of acyclic linker-containing antisense oligonucleotides, and their use for the prevention or depletion of function of a target nucleic acid of interest, such as RNA, in a system. Such a prevention or depletion of function includes, for example, the prevention or inhibition of the expression, reverse transcription and/or replication of the target nucleic acid, as well as the cleavage/degradation of the target nucleic acid. Accordingly, an oligonucleotide of the invention is useful for analytical and therapeutic methods and uses in which the function of a target nucleic acid is implicated, as well as a component of commercial packages corresponding to such methods and uses.
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Inventors:
Dunha, Masad Jay
Viazobkina, Ekaterina
Mariam, Mangos
Paniak, Michael A
Min, Kyung-Ryumu
Viazobkina, Ekaterina
Mariam, Mangos
Paniak, Michael A
Min, Kyung-Ryumu
Application Number:
JP2003540190A
Publication Date:
April 07, 2005
Filing Date:
October 29, 2002
Export Citation:
Assignee:
McGill University
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P43/00; C07H21/00; C07H21/02; C07H21/04; C12N15/85; (IPC1-7): C12N15/09; C07H21/04
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita