Title:
触媒イミダゾール(例えばヒスチジン)機能を有する触媒を使用した安定化変還複合体を用いたアシル移行
Document Type and Number:
Japanese Patent JP4227193
Kind Code:
B2
Abstract:
The invention relates to a method of performing a chemical reaction between a reagent and a substrate, involving an acyl transfer mechanism, in the presence of an imidazole-based catalyst capable of forming a transition complex with the substrate. The catalytic imidazole function is provided by a chemical structure element comprising an optionally substituted imidazolyl group flanked on one or both sides by a group or groups capable of stabilizing the transition complex by molecular interaction with the acyl group. The invention also relates to such a designed chemical structure element, a method of producing it by recombinant DNA techniques and a vector therefor.
Inventors:
Arlberg, Pale
Balzell, Lars
Balzell, Lars
Application Number:
JP54079797A
Publication Date:
February 18, 2009
Filing Date:
May 13, 1997
Export Citation:
Assignee:
MODPRO AB
International Classes:
C07K1/10; C12N15/09; B01J31/02; C07B41/06; C07K1/04; C07K14/00; C12P21/02
Other References:
Biochemistry,1987,Vol.26,p.7246-7250
Nucleic Acids Research,1995,Vol.23,No.23,p.4793-4798
Nucleic Acids Research,1995,Vol.23,No.23,p.4793-4798
Attorney, Agent or Firm:
Haruo Hamada