Title:
アシルアミノ置換縮合シクロペンタンカルボン酸誘導体及び医薬としてのその使用
Document Type and Number:
Japanese Patent JP5785491
Kind Code:
B2
Abstract:
wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Inventors:
Martius Schaeffer
Joseph Pernerstorfer
Dieter Cardellite
Hartmut Straubel
Werngart Cech Twitzky
Charlie El Chen
Arena Safalova
Alexandra Wixell
Marcel Patek
Joseph Pernerstorfer
Dieter Cardellite
Hartmut Straubel
Werngart Cech Twitzky
Charlie El Chen
Arena Safalova
Alexandra Wixell
Marcel Patek
Application Number:
JP2011507810A
Publication Date:
September 30, 2015
Filing Date:
April 22, 2009
Export Citation:
Assignee:
SANOFI
International Classes:
C07C235/54; A61K31/165; A61K31/196; A61K31/216; A61K31/275; A61K31/337; A61K31/341; A61K31/343; A61K31/351; A61K31/357; A61K31/381; A61K31/40; A61K31/4015; A61K31/402; A61K31/4035; A61K31/404; A61K31/415; A61K31/4164; A61K31/4184; A61K31/4192; A61K31/42; A61K31/421; A61K31/423; A61K31/4245; A61K31/426; A61K31/427; A61K31/433; A61K31/435; A61K31/439; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4439; A61K31/445; A61K31/4453; A61K31/495; A61K31/4965; A61K31/498; A61P3/00; A61P5/00; A61P5/14; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P11/06; A61P11/16; A61P13/12; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/18; A61P29/00; A61P35/00; A61P35/04; A61P37/00; A61P37/08; A61P43/00; C07C255/57; C07C309/73; C07C317/46; C07C323/56; C07D207/08; C07D207/27; C07D209/08; C07D209/12; C07D209/44; C07D211/22; C07D213/30; C07D213/61; C07D213/65; C07D213/68; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D213/84; C07D221/04; C07D231/12; C07D233/60; C07D233/84; C07D235/12; C07D241/12; C07D241/36; C07D249/06; C07D261/04; C07D261/08; C07D261/20; C07D263/32; C07D271/08; C07D277/24; C07D277/56; C07D285/06; C07D295/08; C07D295/14; C07D295/18; C07D305/06; C07D307/12; C07D307/78; C07D309/06; C07D319/06; C07D319/20; C07D333/16; C07D333/24; C07D333/28; C07D333/38; C07D333/56; C07D333/60; C07D333/78; C07D413/04; C07D417/04
Domestic Patent References:
| JP2000502356A |
Foreign References:
| WO2006022955A2 | ||||
| WO2006088246A1 |
Other References:
R. Lohmar et al.,Chem. Ber.,1980年,Vol.113,p.3706-3715
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi